Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
activated by neurotransmitters
|
| gptkbp:alsoKnownAs |
Cys-loop ligand-gated ion channels
|
| gptkbp:discoveredBy |
Jean-Pierre Changeux and colleagues
|
| gptkbp:evolvesFrom |
evolved in early metazoans
|
| gptkbp:example |
gptkb:GABA_A_receptor
gptkb:glycine_receptor gptkb:serotonin_5-HT3_receptor gptkb:zinc-activated_ion_channel nicotinic acetylcholine receptor |
| gptkbp:extracellularDomain |
contains ligand-binding site
|
| gptkbp:firstDescribed |
1970s
|
| gptkbp:foundIn |
animals
|
| gptkbp:function |
mediate fast synaptic transmission
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cys-loop receptors
|
| gptkbp:intracellularDomain |
involved in channel regulation
|
| gptkbp:ionConductance |
varies by receptor subtype
|
| gptkbp:location |
central nervous system
peripheral nervous system |
| gptkbp:memberOf |
ligand-gated ion channel superfamily
|
| gptkbp:modulatedBy |
allosterically modulated by various drugs
|
| gptkbp:molecularWeight |
varies by subunit composition
|
| gptkbp:mutationAssociatedWith |
mutations can cause neurological disorders
|
| gptkbp:permeableTo |
permeable to cations or anions depending on subtype
|
| gptkbp:pharmacology |
subject to desensitization
subject to positive and negative allosteric modulation subject to competitive and non-competitive inhibition |
| gptkbp:poreLining |
M2 transmembrane helix
|
| gptkbp:proteinFamily |
CHRNA, GABRA, GLRA, HTR3A, ZACN
|
| gptkbp:relatedTo |
P2X receptors (not Cys-loop family)
ionotropic glutamate receptors (not Cys-loop family) |
| gptkbp:significance |
target for anesthetics
target for anti-epileptic drugs target for antiemetics target for muscle relaxants |
| gptkbp:structure |
contain a characteristic loop formed by a disulfide bond between two cysteine residues
|
| gptkbp:studiedBy |
model for drug screening
model for studying synaptic transmission |
| gptkbp:subunit |
alpha subunit
beta subunit gamma subunit pentameric delta subunit epsilon subunit pi subunit rho subunit theta subunit |
| gptkbp:synapticRole |
mediate inhibitory or excitatory neurotransmission
|
| gptkbp:transmembraneDomains |
four per subunit
|
| gptkbp:bfsParent |
gptkb:pentameric_ligand-gated_ion_channels
|
| gptkbp:bfsLayer |
7
|