Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:cell_membrane
ion channel |
| gptkbp:activatedBy |
agonists
binding of a chemical ligand voltage changes |
| gptkbp:alternativeName |
ionotropic receptor
chemically gated ion channel |
| gptkbp:component |
postsynaptic membrane
|
| gptkbp:composedOf |
multiple subunits
|
| gptkbp:dysregulationAssociatedWith |
gptkb:myasthenia_gravis
epilepsy anxiety disorders |
| gptkbp:evolvesFrom |
prokaryotes and eukaryotes
|
| gptkbp:example |
gptkb:GABA_A_receptor
gptkb:5-HT3_receptor gptkb:glycine_receptor nicotinic acetylcholine receptor ionotropic glutamate receptor |
| gptkbp:firstDescribed |
20th century
|
| gptkbp:foundIn |
gptkb:nervous_system
muscle cells |
| gptkbp:function |
mediate rapid synaptic transmission
|
| https://www.w3.org/2000/01/rdf-schema#label |
ligand-gated ion channels
|
| gptkbp:inhibitedBy |
antagonists
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:modulatedBy |
allosteric modulators
|
| gptkbp:opensInResponseTo |
ligand binding
|
| gptkbp:permeableTo |
ions
|
| gptkbp:proteinFamily |
gptkb:Cys-loop_receptor_family
gptkb:P2X_receptor_family ionotropic glutamate receptor family |
| gptkbp:regulates |
membrane potential
cell excitability |
| gptkbp:researchArea |
gptkb:pharmacy
biochemistry neuroscience |
| gptkbp:role |
muscle contraction
neurotransmission sensory transduction |
| gptkbp:structure |
transmembrane protein complex
|
| gptkbp:subspecies |
anion-selective
cation-selective |
| gptkbp:subunit |
alpha subunit
beta subunit gamma subunit delta subunit |
| gptkbp:target |
pharmaceutical drugs
toxins |
| gptkbp:bfsParent |
gptkb:pentameric_ligand-gated_ion_channels
|
| gptkbp:bfsLayer |
7
|