ligand-gated ion channels

URI: https://gptkb.org/entity/ligand-gated_ion_channels

GPTKB entity

Statements (52)

Predicate	Object
gptkbp:instanceOf	gptkb:cell_membrane gptkb:ion_channel
gptkbp:activatedBy	agonists binding of a chemical ligand voltage changes
gptkbp:alternativeName	gptkb:ionotropic_receptor chemically gated ion channel
gptkbp:component	postsynaptic membrane
gptkbp:composedOf	multiple subunits
gptkbp:dysregulationAssociatedWith	gptkb:myasthenia_gravis epilepsy anxiety disorders
gptkbp:evolvesFrom	prokaryotes and eukaryotes
gptkbp:example	gptkb:ionotropic_glutamate_receptor gptkb:GABA_A_receptor gptkb:5-HT3_receptor gptkb:glycine_receptor nicotinic acetylcholine receptor
gptkbp:firstDescribed	20th century
gptkbp:foundIn	gptkb:nervous_system muscle cells
gptkbp:function	mediate rapid synaptic transmission
gptkbp:inhibitedBy	antagonists
gptkbp:location	gptkb:cell_membrane
gptkbp:modulatedBy	allosteric modulators
gptkbp:opensInResponseTo	ligand binding
gptkbp:permeableTo	ions
gptkbp:proteinFamily	gptkb:Cys-loop_receptor_family gptkb:P2X_receptor_family ionotropic glutamate receptor family
gptkbp:regulates	membrane potential cell excitability
gptkbp:researchArea	gptkb:pharmacy biochemistry neuroscience
gptkbp:role	muscle contraction neurotransmission sensory transduction
gptkbp:structure	transmembrane protein complex
gptkbp:subspecies	anion-selective cation-selective
gptkbp:subunit	alpha subunit beta subunit gamma subunit delta subunit
gptkbp:target	pharmaceutical drugs toxins
gptkbp:bfsParent	gptkb:serotonin_(5-HT) gptkb:pentameric_ligand-gated_ion_channels gptkb:calcium_ion_channels
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	ligand-gated ion channels