|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
neurotransmitters
|
|
gptkbp:alternativeName
|
gptkb:Cys-loop_receptors
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:myasthenia_gravis
epilepsy
schizophrenia
anxiety disorders
|
|
gptkbp:evolvesFrom
|
ancient and conserved
|
|
gptkbp:foundIn
|
gptkb:nervous_system
invertebrates
vertebrates
|
|
gptkbp:function
|
mediate fast synaptic transmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pLGICs
|
|
gptkbp:includes
|
gptkb:GABA_A_receptor
gptkb:glycine_receptor
gptkb:serotonin_5-HT3_receptor
nicotinic acetylcholine receptor
|
|
gptkbp:ionSelectivity
|
anion-selective
cation-selective
|
|
gptkbp:mechanismOfAction
|
ligand binding opens ion channel
|
|
gptkbp:membraneLocation
|
gptkb:cell_membrane
|
|
gptkbp:proteinFamily
|
Cys-loop receptor gene family
|
|
gptkbp:role
|
regulate neuronal excitability
mediate inhibitory and excitatory signals
|
|
gptkbp:standsFor
|
gptkb:pentameric_ligand-gated_ion_channels
|
|
gptkbp:structure
|
pentameric
|
|
gptkbp:studiedIn
|
gptkb:pharmacy
neuroscience
|
|
gptkbp:subunit
|
five subunits
|
|
gptkbp:target
|
drugs
neurotoxins
anesthetics
|
|
gptkbp:bfsParent
|
gptkb:pentameric_ligand-gated_ion_channels
|
|
gptkbp:bfsLayer
|
7
|