|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:S6K1
gptkb:p70S6K
gptkb:STK14A
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredBy
|
researchers in the 1990s
|
|
gptkbp:encodes
|
gptkb:ribosomal_protein_S6_kinase_beta-1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108443
6198
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
cell proliferation
cell growth
regulation of protein synthesis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasIsoform
|
gptkb:p70_S6K1
gptkb:p85_S6K1
|
|
gptkbp:HGNC_ID
|
10436
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RPS6KB1
|
|
gptkbp:inhibitedBy
|
gptkb:rapamycin
|
|
gptkbp:involvedIn
|
gptkb:mTOR_signaling_pathway
|
|
gptkbp:length
|
525 amino acids (canonical isoform)
|
|
gptkbp:locatedOnChromosome
|
17q23.1
|
|
gptkbp:memberOf
|
gptkb:AGC_kinase_family
|
|
gptkbp:molecularWeight
|
59 kDa (canonical isoform)
|
|
gptkbp:OMIM
|
608938
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Rps6kb1
|
|
gptkbp:phosphorylates
|
gptkb:mTOR
Ser371
Ser411
Ser424
Ser427
Thr389
Thr229
|
|
gptkbp:product
|
gptkb:p70_ribosomal_protein_S6_kinase
|
|
gptkbp:regulates
|
gptkb:ribosomal_protein_S6
translation initiation
activated by growth factors
activated by insulin
activated by mitogens
activated by nutrients
inhibited by AMPK
inhibited by energy stress
inhibited by rapamycin
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P23443
|
|
gptkbp:bfsParent
|
gptkb:S6K
gptkb:S6K1
gptkb:M6K
|
|
gptkbp:bfsLayer
|
6
|