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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
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gptkb:E1A_binding_protein_p300
gptkb:KAT3B
|
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gptkbp:associatedWith
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gptkb:cancer
gptkb:Rubinstein-Taybi_syndrome
|
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gptkbp:biologicalProcess
|
DNA repair
cell cycle regulation
regulation of transcription
chromatin remodeling
|
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gptkbp:cellularComponent
|
chromatin
nucleoplasm
|
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gptkbp:cofactor
|
acetyl-CoA
|
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gptkbp:domain
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gptkb:HAT_domain
gptkb:KIX_domain
gptkb:TAZ_domain
gptkb:bromodomain
CH1 domain
CH2 domain
CH3 domain
|
|
gptkbp:encodedBy
|
EP300 gene
|
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gptkbp:Entrez_Gene_ID
|
2033
|
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gptkbp:function
|
histone acetyltransferase activity
transcriptional coactivator
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p300 protein
|
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gptkbp:interactsWith
|
gptkb:CBP_protein
gptkb:STAT_proteins
gptkb:NF-kB
gptkb:p53_protein
CREB protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_22q13.2
|
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gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~300 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
tumorigenesis
|
|
gptkbp:OMIM
|
602700
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
mouse Ep300 protein
rat Ep300 protein
|
|
gptkbp:PDB
|
gptkb:4PZS
5HOU
3BIY
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:reviewedBy
|
gptkb:science
gptkb:Nature_Reviews_Molecular_Cell_Biology
Cell
|
|
gptkbp:UniProtID
|
gptkb:Q09472
|
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gptkbp:bfsParent
|
gptkb:C-myb_protein
gptkb:KIX_domain
gptkb:MIZ-1_protein
|
|
gptkbp:bfsLayer
|
8
|