Statements (104)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
Rhodopsin-like GPCRs
|
| gptkbp:characteristic |
seven transmembrane domains
|
| gptkbp:conservedIn |
CWxP motif
DRY motif E/DRY motif NPxxY motif PIF motif ionic lock microswitches toggle switch |
| gptkbp:contains |
gptkb:rhodopsin
gptkb:cannabinoid_receptors gptkb:opioid_receptors gptkb:angiotensin_receptors gptkb:free_fatty_acid_receptors gptkb:melatonin_receptors gptkb:muscarinic_acetylcholine_receptors gptkb:purinergic_receptors gptkb:trace_amine-associated_receptors gptkb:vasopressin_receptors adrenergic receptors dopamine receptors histamine receptors serotonin receptors olfactory receptors melanocortin receptors bombesin receptors bradykinin receptors calcitonin receptors cholecystokinin receptors endothelin receptors galanin receptors glucagon receptors gonadotropin-releasing hormone receptors kisspeptin receptors neuropeptide Y receptors neurotensin receptors orexin receptors parathyroid hormone receptors prostaglandin receptors somatostatin receptors tachykinin receptors thyrotropin-releasing hormone receptors formyl peptide receptors neurokinin receptors prokineticin receptors secretin receptors vasoactive intestinal peptide receptors adiponectin receptors adrenocorticotropic hormone receptors apelin receptors chemerin receptors corticotropin-releasing hormone receptors ghrelin receptors growth hormone-releasing hormone receptors motilin receptors orphan GPCRs |
| gptkbp:determines |
X-ray crystallography
cryo-electron microscopy |
| gptkbp:discoveredBy |
gptkb:Robert_Lefkowitz
|
| gptkbp:encodedBy |
GPCR genes
|
| gptkbp:foundIn |
gptkb:metazoans
|
| gptkbp:function |
signal transduction
|
| https://www.w3.org/2000/01/rdf-schema#label |
Class A GPCRs
|
| gptkbp:involvedIn |
sensory perception
immune response neurotransmission hormone signaling |
| gptkbp:ligand |
light
lipids nucleotides peptides biogenic amines |
| gptkbp:numberOfMembers |
over 700 in humans
|
| gptkbp:significance |
gptkb:Alzheimer's_disease
gptkb:COVID-19 gptkb:Parkinson's_disease gptkb:cancer gptkb:depression gptkb:diabetes gptkb:autism_spectrum_disorder asthma epilepsy infectious diseases schizophrenia obesity pain HIV infection drug addiction hypertension cardiovascular diseases inflammatory diseases neurological disorders metabolic diseases glaucoma allergies migraine psychiatric disorders |
| gptkbp:subclassOf |
gptkb:G_protein-coupled_receptors
|
| gptkbp:target |
many drugs
|
| gptkbp:bfsParent |
gptkb:G_protein-coupled_receptors_(Class_IB)
gptkb:rhodopsin-like_receptor |
| gptkbp:bfsLayer |
6
|