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gptkbp:instanceOf
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gptkb:protein
gptkb:G_protein-coupled_receptor
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gptkbp:alsoKnownAs
|
gptkb:Class_A_GPCRs
|
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gptkbp:contains
|
gptkb:rhodopsin
gptkb:opioid_receptors
gptkb:muscarinic_acetylcholine_receptors
adrenergic receptors
dopamine receptors
serotonin receptors
olfactory receptors
|
|
gptkbp:database
|
HGNC: 4396
Reactome: R-HSA-373076
UniProt: P08100
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gptkbp:discoveredBy
|
gptkb:Robert_J._Lefkowitz
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|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:domain
|
7TM domain
|
|
gptkbp:encodedBy
|
various genes
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gptkbp:evolvesFrom
|
gptkb:metazoans
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gptkbp:foundIn
|
animals
|
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gptkbp:function
|
signal transduction
|
|
gptkbp:GO_term
|
GO:0004930
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
rhodopsin-like GPCRs
|
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gptkbp:importantFor
|
gptkb:DVD
neurotransmission
olfaction
hormone signaling
|
|
gptkbp:InterPro
|
IPR000276
|
|
gptkbp:involvedIn
|
sensory perception
immune response
cell communication
cardiovascular regulation
|
|
gptkbp:ligand
|
light
lipids
nucleotides
amines
peptides
|
|
gptkbp:modulatedBy
|
phosphorylation
allosteric modulators
arrestins
|
|
gptkbp:mutationAssociatedWith
|
retinitis pigmentosa
congenital stationary night blindness
various neurological disorders
|
|
gptkbp:numberOfMembers
|
over 700 in humans
|
|
gptkbp:proteinFamily
|
PF00001
|
|
gptkbp:structure
|
seven transmembrane helices
|
|
gptkbp:subclassOf
|
gptkb:GPCR_superfamily
|
|
gptkbp:target
|
many drugs
|
|
gptkbp:transducesSignalVia
|
heterotrimeric G proteins
|
|
gptkbp:bfsParent
|
gptkb:MT1_receptor
|
|
gptkbp:bfsLayer
|
7
|