|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
M3R
mAChR M3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:COPD
asthma
Sjogren's syndrome
overactive bladder
smooth muscle contraction
glandular secretion
central nervous system function
|
|
gptkbp:discoveredBy
|
gene cloning
|
|
gptkbp:encodes
|
muscarinic acetylcholine receptor M3
|
|
gptkbp:enemyOf
|
gptkb:acetylcholine
atropine
tiotropium
darifenacin
|
|
gptkbp:Entrez_Gene_ID
|
1131
ENSG00000133019
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
gastrointestinal tract
bladder
|
|
gptkbp:fullName
|
cholinergic receptor muscarinic 3
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
mediates acetylcholine signaling
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:1950
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHRM3
|
|
gptkbp:length
|
590 amino acids
|
|
gptkbp:locatedOnChromosome
|
1q43
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
65 kDa
|
|
gptkbp:OMIM
|
118494
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Chrm3
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
muscarinic acetylcholine receptor family
|
|
gptkbp:recipient
|
gptkb:muscarinic_acetylcholine_receptor
|
|
gptkbp:regulates
|
regulated by acetylcholine
regulated by muscarinic agonists and antagonists
|
|
gptkbp:symbol
|
gptkb:CHRM3
|
|
gptkbp:targetOfDrug
|
yes
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:type
|
Gq/11 protein pathway
|
|
gptkbp:UniProtID
|
P20309
|
|
gptkbp:bfsParent
|
gptkb:muscarinic_acetylcholine_receptor
|
|
gptkbp:bfsLayer
|
6
|