mitogen-activated protein kinase (MAPK) pathway

URI: https://gptkb.org/entity/mitogen-activated_protein_kinase_(MAPK)_pathway
GPTKB entity
Statements (38)
Predicate Object
gptkbp:instanceOf signaling molecule
gptkbp:activatedBy cytokines
growth factors
mitogens
stress signals
gptkbp:alsoKnownAs gptkb:MAPK_pathway
gptkbp:component gptkb:ERK_pathway
gptkb:MAP_kinase_kinase_(MAP2K)
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
gptkb:MAP_kinase_(MAPK)
gptkb:MAP_kinase_kinase_kinase_(MAP3K)
gptkbp:dysregulationAssociatedWith gptkb:cancer
neurodegenerative diseases
inflammatory diseases
gptkbp:firstDescribed 1990s
gptkbp:foundIn eukaryotic cells
https://www.w3.org/2000/01/rdf-schema#label mitogen-activated protein kinase (MAPK) pathway
gptkbp:involves gptkb:Ras_protein
transcription factors
phosphorylation cascade
ERK protein
MEK protein
Raf protein
sequential activation of kinases
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
cell survival
gene expression
cell migration
gptkbp:studiedIn cell biology
immunology
neuroscience
oncology
gptkbp:target therapeutic drugs
gptkbp:bfsParent gptkb:Extracellular_signal-regulated_kinases_(ERKs)
gptkbp:bfsLayer 7