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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
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gptkb:CD18
gptkb:ITGB2
gptkb:LFA-1_beta_chain
gptkb:Leukocyte_adhesion_glycoprotein_beta_chain
|
|
gptkbp:component
|
leukocyte integrins
|
|
gptkbp:discoveredBy
|
1980s
|
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gptkbp:encodedBy
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gptkb:ITGB2_gene
|
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gptkbp:expressedIn
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gptkb:leukocytes
|
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gptkbp:formsHeterodimerWith
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gptkb:integrin_alpha_M_(CD11b)
gptkb:integrin_alpha_D_(CD11d)
gptkb:integrin_alpha_L_(CD11a)
gptkb:integrin_alpha_X_(CD11c)
|
|
gptkbp:foundIn
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gptkb:Homo_sapiens
|
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gptkbp:function
|
immune response
cell adhesion
leukocyte migration
|
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gptkbp:gene
|
gptkb:ITGB2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
integrin beta 2 (CD18)
|
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gptkbp:interactsWith
|
gptkb:ICAM-1
gptkb:ICAM-2
gptkb:ICAM-3
|
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gptkbp:locatedOnChromosome
|
21q22.3
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
90 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:leukocyte_adhesion_deficiency_type_1
|
|
gptkbp:OMIM
|
600065
|
|
gptkbp:PDB
|
3K6S
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
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gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:UniProtID
|
P05107
|
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gptkbp:bfsParent
|
gptkb:CR3_domain
|
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gptkbp:bfsLayer
|
6
|