|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD54
|
|
gptkbp:antibodyTarget
|
therapeutic antibodies
|
|
gptkbp:biologicalProcess
|
signal transduction
antigen presentation
immune cell migration
|
|
gptkbp:cellTypeExpression
|
endothelial cells
immune cells
epithelial cells
|
|
gptkbp:discoveredBy
|
Rothlein et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
Ig-like C2-type domains
|
|
gptkbp:encodedBy
|
gptkb:ICAM1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000090339
|
|
gptkbp:fullName
|
gptkb:Intercellular_Adhesion_Molecule_1
|
|
gptkbp:function
|
immune response
cell adhesion
leukocyte transmigration
|
|
gptkbp:gene
|
gptkb:ICAM1
|
|
gptkbp:glycosylation
|
N-linked
|
|
gptkbp:GO
|
GO:0007155 (cell adhesion)
GO:0005515 (protein binding)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human ICAM1
|
|
gptkbp:inducedBy
|
gptkb:IL-1
gptkb:TNF-alpha
gptkb:IFN-gamma
cytokines
|
|
gptkbp:interactsWith
|
gptkb:LFA-1
gptkb:Mac-1
|
|
gptkbp:length
|
505 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~85 kDa
|
|
gptkbp:OMIM
|
147840
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse ICAM1
rat ICAM1
|
|
gptkbp:PDB
|
gptkb:1IC1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NP_000192.2
|
|
gptkbp:role
|
atherosclerosis
autoimmune diseases
inflammation
cancer metastasis
|
|
gptkbp:structure
|
type I transmembrane glycoprotein
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P05362
|
|
gptkbp:bfsParent
|
gptkb:mouse_Icam1
gptkb:rat_Icam1
|
|
gptkbp:bfsLayer
|
8
|