Intercellular Adhesion Molecule 1

URI: https://gptkb.org/entity/Intercellular_Adhesion_Molecule_1
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:abbreviation gptkb:ICAM-1
gptkbp:alternativeSplicing yes
gptkbp:associatedWith atherosclerosis
autoimmune diseases
inflammation
gptkbp:binds gptkb:LFA-1
gptkb:Mac-1
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy gptkb:Tim_Springer
gptkbp:discoveredIn 1986
gptkbp:encodedBy gptkb:ICAM1_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000090339
3383
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
heart
liver
spleen
lymph node
endothelial cells
immune cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function immune response
cell adhesion
leukocyte endothelial transmigration
cell adhesion molecule activity
gptkbp:glycosylation yes
gptkbp:GOProcess immune response
leukocyte migration
gptkbp:HGNC_ID gptkb:ICAM1
https://www.w3.org/2000/01/rdf-schema#label Intercellular Adhesion Molecule 1
gptkbp:length 505 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_19
gptkbp:memberOf gptkb:immunoglobulin_superfamily
gptkbp:molecularWeight 55-110 kDa
gptkbp:OMIM 147840
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1IC1
gptkbp:RefSeq NM_000201
gptkbp:structure single-pass type I membrane protein
gptkbp:UniProtID gptkb:P05362
gptkbp:upregulatedBy gptkb:IL-1
gptkb:TNF-alpha
cytokines
gptkbp:bfsParent gptkb:ICAM-1
gptkb:ICAM1
gptkbp:bfsLayer 7