|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:FKHRL1
gptkb:FOXO3A
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
human longevity
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:encodes
|
gptkb:FOXO3_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:FOXO3
gptkb:ENSG00000118689
2309
|
|
gptkbp:expressedIn
|
development
many tissues
adulthood
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:hasForkheadDomain
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3821
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human FOXO3
|
|
gptkbp:inhibitedBy
|
insulin signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:memberOf
|
gptkb:FOXO_subfamily
|
|
gptkbp:mutationAssociatedWith
|
increased lifespan in humans
premature ovarian failure
|
|
gptkbp:OMIM
|
602681
|
|
gptkbp:orthologInDrosophila
|
gptkb:dFOXO
|
|
gptkbp:orthologInMouse
|
gptkb:Foxo3
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
gptkb:SGK
|
|
gptkbp:proteinFamily
|
forkhead box O
|
|
gptkbp:regulates
|
gptkb:PI3K-AKT_pathway
apoptosis
longevity
DNA repair
metabolism
immune response
cell cycle
stem cell maintenance
autophagy
oxidative stress response
stress signals
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:transcriptionalRegulatorOf
|
gptkb:GADD45A
gptkb:MnSOD
gptkb:p27Kip1
gptkb:BCL2L11
catalase
|
|
gptkbp:UniProtID
|
O43524
|
|
gptkbp:bfsParent
|
gptkb:C._elegans_DAF-16
|
|
gptkbp:bfsLayer
|
7
|