|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CDKN2
gptkb:p33(CDK2)
|
|
gptkbp:associatedWith
|
gptkb:cancer
cell cycle disorders
|
|
gptkbp:biologicalProcess
|
DNA replication
protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:encodedBy
|
gptkb:CDK2_gene
|
|
gptkbp:Entrez_Gene_ID
|
1017
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.22
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_2
|
|
gptkbp:function
|
regulation of cell cycle
phosphorylation of target proteins
|
|
gptkbp:gene
|
gptkb:CDK2
|
|
gptkbp:hasIsoform
|
CDK2 isoform 1
CDK2 isoform 2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human CDK2
|
|
gptkbp:inhibitedBy
|
gptkb:p21
gptkb:p27
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_A
gptkb:Cyclin_E
|
|
gptkbp:length
|
298 amino acids
|
|
gptkbp:locatedOnChromosome
|
12q13
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Cdk2
gptkb:rat_Cdk2
|
|
gptkbp:pathway
|
cell cycle
p53 signaling pathway
|
|
gptkbp:PDB
|
gptkb:1HCK
1FIN
|
|
gptkbp:phosphorylates
|
Thr160
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:RefSeq
|
gptkb:NP_001789.2
|
|
gptkbp:regulates
|
activated by cyclin binding
inhibited by CDK inhibitors
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
monomer
forms heterodimer with cyclins
|
|
gptkbp:substrate
|
gptkb:Rb_protein
gptkb:NPAT
gptkb:p27Kip1
|
|
gptkbp:subunit
|
forms complex with cyclins
|
|
gptkbp:UniProtID
|
P24941
ENSP00000266970
|
|
gptkbp:bfsParent
|
gptkb:mouse_Cdk2
|
|
gptkbp:bfsLayer
|
8
|