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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:MRP1
gptkb:multidrug_resistance-associated_protein_1
canalicular multispecific organic anion transporter (cMOAT)
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gptkbp:associatedWith
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multidrug resistance in cancer
cystic fibrosis (indirectly, as a related ABC transporter)
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gptkbp:discoveredBy
|
1992
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000103222
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gptkbp:expressedIn
|
widely expressed, especially in lung, testis, kidney, and placenta
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gptkbp:family
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gptkb:ATP-binding_cassette_(ABC)_transporter_family
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gptkbp:fullName
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gptkb:ATP-binding_cassette_sub-family_C_member_1
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gptkbp:function
|
transports organic anions and drugs out of cells
ATPase activity
transmembrane transporter activity
multidrug resistance-associated protein 1 (MRP1)
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gptkbp:gene
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gptkb:ABCC1
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gptkbp:GOProcess
|
drug transport
glutathione conjugate transport
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gptkbp:HGNC_ID
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gptkb:HGNC:54
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|
https://www.w3.org/2000/01/rdf-schema#label
|
human ABCC1
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gptkbp:inhibitors
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gptkb:MK-571
gptkb:probenecid
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gptkbp:length
|
1531 amino acids
|
|
gptkbp:locatedOnChromosome
|
16
16p13.11
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gptkbp:location
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gptkb:plasma_membrane
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gptkbp:molecularWeight
|
171 kDa
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gptkbp:OMIM
|
158343
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologIn
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gptkb:mouse_Abcc1
gptkb:rat_Abcc1
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gptkbp:PDB
|
5UJA
|
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gptkbp:postTranslationalModifications
|
phosphorylation
glycosylation
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gptkbp:relatedTo
|
gptkb:ABCC2
ABCC3
CFTR (ABCC7)
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gptkbp:reviewedBy
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gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
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gptkbp:significance
|
implicated in resistance to chemotherapy
role in drug disposition and pharmacokinetics
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gptkbp:structure
|
contains two ATP-binding domains and multiple transmembrane domains
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gptkbp:subfamily
|
C (CFTR/MRP) subfamily
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gptkbp:substrate
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gptkb:leukotriene_C4
antiviral drugs
antineoplastic agents
glutathione conjugates
organic anions
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gptkbp:UniProtID
|
P33527
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gptkbp:bfsParent
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gptkb:mouse_Abcc1
gptkb:rat_Abcc1
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gptkbp:bfsLayer
|
7
|