ATP-binding cassette sub-family C member 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:ABCC1 gptkb:Multidrug_resistance-associated_protein_1
gptkbp:associatedWith	multidrug resistance in cancer
gptkbp:discoveredBy	gptkb:Cole_et_al.
gptkbp:discoveredIn	1992
gptkbp:encodedBy	gptkb:ABCC1_gene
gptkbp:expressedIn	gptkb:cancer gptkb:kidney gptkb:placenta gptkb:testis gptkb:blood-brain_barrier liver
gptkbp:function	gptkb:multidrug_resistance_protein ATPase activity transmembrane transporter drug transmembrane transporter activity
gptkbp:gene	gptkb:ABCC1
gptkbp:GOProcess	xenobiotic transport glutathione metabolic process
gptkbp:HGNC_ID	HGNC:53
https://www.w3.org/2000/01/rdf-schema#label	ATP-binding cassette sub-family C member 1
gptkbp:involvedIn	export of drugs and xenobiotics export of organic anions
gptkbp:length	1531
gptkbp:locatedOnChromosome	gptkb:16q12.1
gptkbp:location	gptkb:plasma_membrane
gptkbp:memberOf	gptkb:ATP-binding_cassette_transporter_family subfamily C
gptkbp:mutationAssociatedWith	drug resistance cancer chemotherapy failure
gptkbp:OMIM	173350
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Abcc1
gptkbp:PDB	5UJA 6BHU
gptkbp:structure	contains two ATP-binding domains contains two transmembrane domains
gptkbp:UniProtID	P33527
gptkbp:bfsParent	gptkb:ABCC1_gene gptkb:mouse_Abcc1
gptkbp:bfsLayer	7