ATP-binding cassette (ABC) transporter family

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:ABC_transporter_family
gptkbp:contains	ATP-binding cassette domain
gptkbp:enzymeCommissionNumber	3.6.3.-
gptkbp:firstDescribed	1970s
gptkbp:foundIn	gptkb:Bacteria archaea eukaryotes
gptkbp:function	transmembrane transport of various molecules
gptkbp:GO_term	GO:0042626
gptkbp:hasPfam	PF00005
gptkbp:hasPROSITE	PS50893
gptkbp:hasUniProtKeyword	gptkb:cell_membrane gptkb:Transport gptkb:Translocase ATP-binding
https://www.w3.org/2000/01/rdf-schema#label	ATP-binding cassette (ABC) transporter family
gptkbp:includes	gptkb:MRP1 gptkb:P-glycoprotein gptkb:CFTR
gptkbp:InterPro	IPR003439
gptkbp:mechanismOfAction	ATP hydrolysis
gptkbp:mutationAssociatedWith	gptkb:Tangier_disease gptkb:Stargardt_disease cystic fibrosis adrenoleukodystrophy
gptkbp:powerSource	gptkb:ATP
gptkbp:presentIn	human genome fungal genome plant genome
gptkbp:role	cholesterol homeostasis lipid transport multidrug resistance antigen presentation bile acid transport iron transport drug resistance in cancer toxin efflux
gptkbp:structure	two nucleotide-binding domains two transmembrane domains
gptkbp:subfamily	gptkb:ABCD gptkb:ABCE gptkb:ABCF gptkb:ABCG gptkb:ABCC gptkb:ABCA ABCB
gptkbp:superfamily	gptkb:ABC_transporters
gptkbp:transportDirection	efflux influx
gptkbp:bfsParent	gptkb:MDR1_gene gptkb:ABC2 gptkb:ABCG1
gptkbp:bfsLayer	7