voltage-gated potassium channel
GPTKB entity
Statements (120)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:cell_membrane
ion channel Membrane protein |
| gptkbp:activatedBy |
change in membrane voltage
membrane depolarization |
| gptkbp:alternativeName |
Ion_Channel
ligand-gated_ion_channel voltage-gated_sodium_channel |
| gptkbp:blockedIn |
tetrodotoxin
saxitoxin |
| gptkbp:component |
neurons
muscle cells cardiac cells excitable cells neuronal membrane muscle membrane |
| gptkbp:decommissioned |
voltage-dependent mechanism
|
| gptkbp:discoveredBy |
gptkb:Andrew_Huxley
gptkb:Bernard_Katz gptkb:Alan_Hodgkin |
| gptkbp:domain |
pore domain
voltage-sensor domain |
| gptkbp:dysregulationAssociatedWith |
gptkb:Cystic_fibrosis
gptkb:arrhythmia epilepsy Epilepsy ataxia Cardiac arrhythmia long QT syndrome Myotonia |
| gptkbp:encodedBy |
gptkb:KCN_gene_family
SCN gene family Ion channel genes |
| gptkbp:foundIn |
gptkb:Cell_membrane
gptkb:plasma_membrane animal cells Organelle membrane |
| gptkbp:function |
potassium ion transport
regulation of membrane potential initiate action potential propagate action potential Facilitates ion transport across cell membranes |
| gptkbp:gatedBy |
gptkb:Voltage
Temperature Ligand Mechanical force |
| https://www.w3.org/2000/01/rdf-schema#label |
voltage-gated potassium channel
|
| gptkbp:inhibitedBy |
gptkb:4-aminopyridine
gptkb:tetraethylammonium |
| gptkbp:modulatedBy |
gptkb:poisoning
Temperature pH Phosphorylation Drugs antiarrhythmic drugs local anesthetics Membrane potential |
| gptkbp:PDB |
gptkb:2A79
2R9Q 2R9R 2R9S 2R9T 3LUT |
| gptkbp:permeableTo |
gptkb:sodium_ion
potassium ions sodium ions |
| gptkbp:permits |
Calcium ions
Chloride ions Potassium ions Sodium ions |
| gptkbp:proteinFamily |
gptkb:KCND
gptkb:KCNA gptkb:KCNB gptkb:KCNC gptkb:KCNH gptkb:KCNJ gptkb:KCNK gptkb:KCNN gptkb:KCNQ gptkb:Kv |
| gptkbp:regulates |
Cell volume
Cellular excitability Electrical signaling Osmotic balance |
| gptkbp:relatedTo |
gptkb:voltage-gated_potassium_channel
gptkb:arrhythmia gptkb:calcium-activated_potassium_channel epilepsy pain disorders |
| gptkbp:requires |
muscle contraction
Action potential Synaptic transmission Muscle contraction nerve impulse conduction Sensory transduction |
| gptkbp:role |
cardiac action potential
neuronal excitability action potential repolarization |
| gptkbp:structure |
tetramer
Transmembrane protein transmembrane protein Auxiliary subunit Pore-forming subunit |
| gptkbp:studiedBy |
Electrophysiology
Patch clamp technique |
| gptkbp:studiedIn |
Neuroscience
Cardiology Physiology |
| gptkbp:subunit |
alpha subunit
beta subunit |
| gptkbp:target |
Antiepileptic drugs
Antiarrhythmic drugs Local anesthetics |
| gptkbp:type |
Leak channel
Ligand-gated ion channel Mechanically-gated ion channel Voltage-gated ion channel |
| gptkbp:bfsParent |
gptkb:GABA_A_receptor
gptkb:KCNQ1 |
| gptkbp:bfsLayer |
6
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