|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GluA2
GLUR2
GluR-K2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:amendedBy
|
alternative splicing
RNA editing at Q/R site
|
|
gptkbp:associatedWith
|
gptkb:synaptic_plasticity
epilepsy
intellectual disability
neurotransmission
|
|
gptkbp:biologicalProcess
|
synaptic transmission
glutamate receptor activity
regulation of ion transmembrane transport
|
|
gptkbp:cellularComponent
|
postsynaptic membrane
dendrite
|
|
gptkbp:discoveredBy
|
researchers in neuroscience
|
|
gptkbp:encodes
|
Glutamate receptor 2
|
|
gptkbp:Entrez_Gene_ID
|
2891
ENSG00000183454
|
|
gptkbp:expressedIn
|
brain
central nervous system
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:function
|
codes for a subunit of the AMPA-sensitive glutamate receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
yes
|
|
gptkbp:HGNC_ID
|
HGNC:4573
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRIA2
|
|
gptkbp:interactsWith
|
gptkb:GRIA1
gptkb:GRIA3
gptkb:GRIA4
gptkb:TARPs
gptkb:PSD-95
|
|
gptkbp:length
|
883 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
|
|
gptkbp:memberOf
|
AMPA receptor subunit family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autism_spectrum_disorder
intellectual disability
neurodevelopmental disorders
|
|
gptkbp:OMIM
|
138247
|
|
gptkbp:orthologInMouse
|
Gria2
|
|
gptkbp:product
|
gptkb:GluA2
|
|
gptkbp:proteinFamily
|
transmembrane domain
ligand-binding domain
amino-terminal domain
carboxy-terminal domain
|
|
gptkbp:regulates
|
calcium permeability of AMPA receptors
|
|
gptkbp:relatedTo
|
gptkb:AMPA_receptor
glutamatergic synapse
|
|
gptkbp:UniProtID
|
P42262
|
|
gptkbp:bfsParent
|
gptkb:AMPA_receptor
gptkb:P05129_(PKC_gamma)
|
|
gptkbp:bfsLayer
|
7
|