CHEMBL137

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:approvalYear 1976
gptkbp:ATCCode gptkb:C07AB03
gptkbp:bioavailability 40-50%
gptkbp:CASNumber gptkb:29122-68-7
gptkbp:color white
gptkbp:contraindication asthma
severe bradycardia
cardiogenic shock
gptkbp:drugClass beta blocker
gptkbp:excretion gptkb:kidney
gptkbp:form crystalline powder
gptkbp:halfLife 6-7 hours
gptkbp:hasBiologicalActivity IC50 1.2 μM (ADRB2, human)
IC50 26 nM (ADRB1, human)
gptkbp:hasInChIKey METKIMKYRPQLGS-UHFFFAOYSA-N
gptkbp:hasLogP 0.16
gptkbp:hasMolecularFormula C14H22N2O3
gptkbp:haspKa 9.6
gptkbp:hasSMILES CC(C)NCC(COC1=CC=CC=C1O)O
gptkbp:hasUNII 50VV3VW0TI
https://www.w3.org/2000/01/rdf-schema#label CHEMBL137
gptkbp:indication gptkb:arrhythmia
myocardial infarction
hypertension
angina pectoris
gptkbp:isApprovedDrug true
gptkbp:isMarketed true
gptkbp:legalStatus expired
prescription only
gptkbp:mechanismOfAction beta-1 adrenergic receptor antagonist
gptkbp:meltingPoint 152-155°C
gptkbp:metabolism liver
gptkbp:molecularWeight 266.34
gptkbp:name gptkb:Atenolol
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 6-16%
gptkbp:PubChem_CID 2162
CHEBI:2269
DB00335
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect dizziness
fatigue
bradycardia
cold extremities
gptkbp:solubility water soluble
gptkbp:synonym gptkb:Atenololum
gptkb:Tenormin
gptkbp:target gptkb:ADRB1
gptkb:ADRB2
gptkbp:therapeuticArea cardiovascular system
gptkbp:bfsParent gptkb:N-acetylcysteine
gptkb:enalapril
gptkbp:bfsLayer 6