gptkbp:instanceOf
|
gptkb:chemical_compound
|
gptkbp:approvalYear
|
1976
|
gptkbp:ATCCode
|
gptkb:C07AB03
|
gptkbp:bioavailability
|
40-50%
|
gptkbp:CASNumber
|
gptkb:29122-68-7
|
gptkbp:color
|
white
|
gptkbp:contraindication
|
asthma
severe bradycardia
cardiogenic shock
|
gptkbp:drugClass
|
beta blocker
|
gptkbp:excretion
|
gptkb:kidney
|
gptkbp:form
|
crystalline powder
|
gptkbp:halfLife
|
6-7 hours
|
gptkbp:hasBiologicalActivity
|
IC50 1.2 μM (ADRB2, human)
IC50 26 nM (ADRB1, human)
|
gptkbp:hasInChIKey
|
METKIMKYRPQLGS-UHFFFAOYSA-N
|
gptkbp:hasLogP
|
0.16
|
gptkbp:hasMolecularFormula
|
C14H22N2O3
|
gptkbp:haspKa
|
9.6
|
gptkbp:hasSMILES
|
CC(C)NCC(COC1=CC=CC=C1O)O
|
gptkbp:hasUNII
|
50VV3VW0TI
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHEMBL137
|
gptkbp:indication
|
gptkb:arrhythmia
myocardial infarction
hypertension
angina pectoris
|
gptkbp:isApprovedDrug
|
true
|
gptkbp:isMarketed
|
true
|
gptkbp:legalStatus
|
expired
prescription only
|
gptkbp:mechanismOfAction
|
beta-1 adrenergic receptor antagonist
|
gptkbp:meltingPoint
|
152-155°C
|
gptkbp:metabolism
|
liver
|
gptkbp:molecularWeight
|
266.34
|
gptkbp:name
|
gptkb:Atenolol
|
gptkbp:pregnancyCategory
|
C (US)
|
gptkbp:proteinBinding
|
6-16%
|
gptkbp:PubChem_CID
|
2162
CHEBI:2269
DB00335
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
gptkbp:sideEffect
|
dizziness
fatigue
bradycardia
cold extremities
|
gptkbp:solubility
|
water soluble
|
gptkbp:synonym
|
gptkb:Atenololum
gptkb:Tenormin
|
gptkbp:target
|
gptkb:ADRB1
gptkb:ADRB2
|
gptkbp:therapeuticArea
|
cardiovascular system
|
gptkbp:bfsParent
|
gptkb:N-acetylcysteine
gptkb:enalapril
|
gptkbp:bfsLayer
|
6
|