|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvedBy
|
1966
|
|
gptkbp:ATCCode
|
gptkb:N06AA04
|
|
gptkbp:availableOn
|
gptkb:tablet
capsule
|
|
gptkbp:brand
|
gptkb:Anafranil
Clomicalm
|
|
gptkbp:CASNumber
|
gptkb:303-49-1
|
|
gptkbp:chemicalFormula
|
gptkb:C19H23ClN2
|
|
gptkbp:contraindication
|
recent myocardial infarction
concurrent MAOI use
hypersensitivity to clomipramine
|
|
gptkbp:developedBy
|
gptkb:Ciba-Geigy
|
|
gptkbp:drugClass
|
antidepressant
|
|
gptkbp:eliminationHalfLife
|
32 hours
|
|
gptkbp:genericName
|
gptkb:clomipramine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Anafranil
|
|
gptkbp:interactsWith
|
gptkb:SSRIs
CYP2D6 inhibitors
anticholinergic drugs
MAOIs
|
|
gptkbp:KEGGID
|
gptkb:D07714
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibition
serotonin reuptake inhibition
|
|
gptkbp:MedlinePlusID
|
a697002
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL137
gptkb:DB01242
2801
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
constipation
weight gain
sweating
drowsiness
dry mouth
sexual dysfunction
|
|
gptkbp:UNII
|
N5VZ4114W2
|
|
gptkbp:usedFor
|
gptkb:depression
gptkb:obsessive-compulsive_disorder
gptkb:panic_disorder
chronic pain
cataplexy
body dysmorphic disorder (off-label)
chronic pain (off-label)
enuresis (off-label)
trichotillomania (off-label)
|
|
gptkbp:usedInVeterinaryMedicine
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Clomipramine
gptkb:clomipramine
|
|
gptkbp:bfsLayer
|
7
|