|
gptkbp:instanceOf
|
gptkb:protein
gptkb:solute_carrier_family
amino acid transporter
|
|
gptkbp:alternativeName
|
gptkb:5-HTT
gptkb:SERT
gptkb:solute_carrier_family_6_member_4
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety disorders
irritable bowel syndrome
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:expressedIn
|
gptkb:placenta
central nervous system
platelets
|
|
gptkbp:foundIn
|
presynaptic neuron membrane
|
|
gptkbp:function
|
reuptake of serotonin from synaptic cleft
regulation of serotonin signaling
|
|
gptkbp:gene
|
gptkb:SLC6A4
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
gptkbp:HGNC_ID
|
11050
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Serotonin transporter
|
|
gptkbp:inhibitedBy
|
gptkb:citalopram
gptkb:escitalopram
gptkb:paroxetine
gptkb:sertraline
gptkb:venlafaxine
gptkb:MDMA
gptkb:amitriptyline
gptkb:imipramine
gptkb:duloxetine
gptkb:fluoxetine
gptkb:clomipramine
gptkb:dextroamphetamine
gptkb:methylphenidate
cocaine
amphetamine
mazindol
sibutramine
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
12 transmembrane domains
|
|
gptkbp:target
|
gptkb:tricyclic_antidepressants
gptkb:MDMA
gptkb:selective_serotonin_reuptake_inhibitors
cocaine
amphetamines
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:P31645
gptkb:DB01452
|
|
gptkbp:bfsLayer
|
7
|