|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:abnormalFunctionLeadsTo
|
gptkb:anemia
infertility
pigmentation disorders
|
|
gptkbp:alternativeName
|
gptkb:CD117
|
|
gptkbp:discoveredBy
|
Toshio Hirai
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
|
|
gptkbp:downstreamOf
|
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkb:RAS/MAPK_pathway
|
|
gptkbp:encodedBy
|
gptkb:KIT_gene
|
|
gptkbp:expressedIn
|
gptkb:melanocytes
gptkb:interstitial_cells_of_Cajal
gptkb:germ_cells
hematopoietic stem cells
|
|
gptkbp:foundIn
|
humans
mice
other mammals
|
|
gptkbp:function
|
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
cell signal transduction
|
|
gptkbp:HGNC_ID
|
6342
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Kit receptor
|
|
gptkbp:ligand
|
gptkb:stem_cell_factor
|
|
gptkbp:locatedOnChromosome
|
chromosome 4q12 (human)
|
|
gptkbp:membraneLocalization
|
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:mastocytosis
gptkb:acute_myeloid_leukemia
gastrointestinal stromal tumors
piebladism
|
|
gptkbp:OMIM
|
164920
|
|
gptkbp:orthologIn
|
mouse (W locus)
|
|
gptkbp:phosphorylates
|
activates downstream signaling pathways
|
|
gptkbp:role
|
melanogenesis
gastrointestinal motility
hematopoiesis
gametogenesis
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:target
|
gptkb:dasatinib
gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
P10721
|
|
gptkbp:bfsParent
|
gptkb:Stem_Cell_Factor
|
|
gptkbp:bfsLayer
|
7
|