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gptkbp:instanceOf
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gptkb:receptor_tyrosine_kinase
gptkb:protein
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gptkbp:alternativeName
|
gptkb:CD117
gptkb:proto-oncogene_c-Kit
stem cell factor receptor
|
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gptkbp:category
|
tumor suppressor
cell surface receptor
CD antigen
enzyme-linked receptor
|
|
gptkbp:discoveredBy
|
Takaku et al.
|
|
gptkbp:discoveredIn
|
1987
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gptkbp:encodedBy
|
gptkb:KIT_gene
|
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gptkbp:expressedIn
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gptkb:melanocytes
gptkb:mast_cells
gptkb:interstitial_cells_of_Cajal
gptkb:germ_cells
hematopoietic stem cells
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gptkbp:function
|
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
cell signal transduction
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gptkbp:HGNC_ID
|
6342
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-KIT (CD117)
|
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gptkbp:ligand
|
stem cell factor (SCF)
|
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gptkbp:locatedOn
|
gptkb:chromosome_4
|
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gptkbp:molecularWeight
|
145 kDa
|
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gptkbp:mutationAssociatedWith
|
gptkb:systemic_mastocytosis
germ cell tumors
familial piebaldism
|
|
gptkbp:OMIM
|
164920
|
|
gptkbp:orthologIn
|
mouse (Kit)
rat (Kit)
|
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gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:significance
|
gptkb:mastocytosis
melanoma
acute myeloid leukemia (AML)
gastrointestinal stromal tumors (GIST)
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gptkbp:structure
|
extracellular domain
transmembrane domain
intracellular kinase domain
|
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gptkbp:target
|
gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
P10721
|
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gptkbp:bfsParent
|
gptkb:KITLG
gptkb:seminoma
|
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gptkbp:bfsLayer
|
8
|