Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
hematologic neoplasm |
| gptkbp:affects |
gptkb:skin
gptkb:mast_cells gastrointestinal tract liver lymph nodes spleen bone marrow |
| gptkbp:associatedWith |
KIT gene mutation
|
| gptkbp:characterizedBy |
abnormal proliferation of mast cells
|
| gptkbp:complication |
gptkb:bone
organ dysfunction anaphylactic shock |
| gptkbp:diagnosedBy |
bone marrow biopsy
immunohistochemistry molecular genetic testing serum tryptase level |
| gptkbp:field |
immunology
hematology |
| gptkbp:firstDescribed |
1949
|
| https://www.w3.org/2000/01/rdf-schema#label |
systemic mastocytosis
|
| gptkbp:ICD-10_code |
D47.02
|
| gptkbp:prevalence |
rare
|
| gptkbp:riskFactor |
gptkb:KIT_D816V_mutation
|
| gptkbp:subspecies |
gptkb:aggressive_systemic_mastocytosis
gptkb:indolent_systemic_mastocytosis gptkb:mast_cell_leukemia gptkb:smoldering_systemic_mastocytosis systemic mastocytosis with associated hematologic neoplasm |
| gptkbp:symptom |
nausea
vomiting diarrhea abdominal pain fatigue weight loss anaphylaxis hepatosplenomegaly bone pain flushing |
| gptkbp:treatment |
gptkb:cladribine
gptkb:midostaurin chemotherapy corticosteroids tyrosine kinase inhibitors antihistamines interferon alpha |
| gptkbp:bfsParent |
gptkb:Rydapt
|
| gptkbp:bfsLayer |
5
|