|
gptkbp:instanceOf
|
gptkb:disease
gptkb:hematologic_neoplasm
|
|
gptkbp:affects
|
gptkb:skin
gptkb:mast_cells
gastrointestinal tract
liver
lymph nodes
spleen
bone marrow
|
|
gptkbp:associatedWith
|
KIT gene mutation
|
|
gptkbp:characterizedBy
|
abnormal proliferation of mast cells
|
|
gptkbp:complication
|
gptkb:bone
organ dysfunction
anaphylactic shock
|
|
gptkbp:diagnosedBy
|
bone marrow biopsy
immunohistochemistry
molecular genetic testing
serum tryptase level
|
|
gptkbp:field
|
immunology
hematology
|
|
gptkbp:firstDescribed
|
1949
|
|
gptkbp:ICD-10_code
|
D47.02
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:riskFactor
|
gptkb:KIT_D816V_mutation
|
|
gptkbp:subspecies
|
gptkb:aggressive_systemic_mastocytosis
gptkb:indolent_systemic_mastocytosis
gptkb:mast_cell_leukemia
gptkb:smoldering_systemic_mastocytosis
systemic mastocytosis with associated hematologic neoplasm
|
|
gptkbp:symptom
|
nausea
vomiting
diarrhea
abdominal pain
fatigue
weight loss
anaphylaxis
hepatosplenomegaly
bone pain
flushing
|
|
gptkbp:treatment
|
gptkb:cladribine
gptkb:interferon_alpha
gptkb:midostaurin
chemotherapy
corticosteroids
tyrosine kinase inhibitors
antihistamines
|
|
gptkbp:bfsParent
|
gptkb:imatinib_(Gleevec)
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
systemic mastocytosis
|