Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetically modified organism
|
| gptkbp:canBe |
disease models
conditional gene expression models conditional knockout constitutive knockout gene knock-in models gene knockout models humanized mouse models knock-in overexpression models reporter mouse models transgene overexpression models |
| gptkbp:createdBy |
CRISPR/Cas9 genome editing
embryonic stem cell manipulation inserting foreign DNA into mouse genome pronuclear injection viral vector-mediated gene transfer |
| gptkbp:developedBy |
1980s
|
| gptkbp:expressedIn |
oncogenes
knockout genes mutant human genes reporter genes |
| gptkbp:hasModel |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease gptkb:cancer gptkb:diabetes gptkb:Huntington's_disease infectious diseases cardiovascular diseases autoimmune diseases cystic fibrosis muscular dystrophy |
| https://www.w3.org/2000/01/rdf-schema#label |
transgenic mouse models
|
| gptkbp:maintainedBy |
breeding colonies
|
| gptkbp:mayInclude |
tissue-specific expression
inducible expression ubiquitous expression |
| gptkbp:regulates |
gptkb:government_agency
institutional animal care and use committees |
| gptkbp:requires |
genotyping
ethical approval phenotyping |
| gptkbp:usedFor |
studying gene function
modeling human diseases |
| gptkbp:usedIn |
biomedical research
cancer research neuroscience research immunology research |
| gptkbp:bfsParent |
gptkb:tau_protein
gptkb:SOD1_gene_mutation gptkb:Tau_protein |
| gptkbp:bfsLayer |
7
|