|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity
|
endopeptidase
ATP-independent
thiol-sensitive
|
|
gptkbp:alsoKnownAs
|
gptkb:IDE
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:type_2_diabetes
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:discoveredBy
|
Ralph A. DeFelice
|
|
gptkbp:discoveredIn
|
1949
|
|
gptkbp:EC_number
|
3.4.24.56
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
liver
pancreas
|
|
gptkbp:family
|
M16 metallopeptidase family
|
|
gptkbp:foundIn
|
mitochondria
cytosol
peroxisomes
|
|
gptkbp:function
|
degrades amyloid-beta peptide
degrades insulin
|
|
gptkbp:gene
|
gptkb:IDE
|
|
gptkbp:GO_term
|
GO:0004222
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
insulin-degrading enzyme
|
|
gptkbp:inhibitedBy
|
gptkb:bacitracin
gptkb:N-ethylmaleimide
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:peroxisome
mitochondrion
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q23-q25
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
linked to Alzheimer's disease risk
linked to hyperinsulinemia
|
|
gptkbp:OMIM
|
146680
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila IDE
mouse IDE
rat IDE
|
|
gptkbp:PDB
|
2G47
|
|
gptkbp:regulates
|
regulated by redox state
regulated by substrate availability
|
|
gptkbp:structure
|
zinc metalloprotease
|
|
gptkbp:substrate
|
gptkb:glucagon
gptkb:insulin
gptkb:amyloid-beta
amylin
|
|
gptkbp:UniProtID
|
P14735
|
|
gptkbp:bfsParent
|
gptkb:varicella-zoster_virus
|
|
gptkbp:bfsLayer
|
6
|