|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
heart failure
leukemia
|
|
gptkbp:biologicalProcess
|
metalloendopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
integral component of membrane
extracellular exosome
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:EC_number
|
3.4.24.11
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
brain
heart
liver
spleen
colon
pancreas
neutrophils
|
|
gptkbp:function
|
degrades peptides such as enkephalins, substance P, and natriuretic peptides
|
|
gptkbp:gene
|
gptkb:MME
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
neprilysin
|
|
gptkbp:inhibitedBy
|
gptkb:sacubitril
racecadotril
|
|
gptkbp:locatedOnChromosome
|
chromosome 3q25
|
|
gptkbp:location
|
gptkb:cancer
gptkb:cell_membrane
gptkb:kidney
brain
liver
neutrophils
|
|
gptkbp:OMIM
|
120520
|
|
gptkbp:otherName
|
gptkb:CD10
neutral endopeptidase
CALLA
|
|
gptkbp:significance
|
marker for acute lymphoblastic leukemia
target for heart failure therapy
|
|
gptkbp:structure
|
type II integral membrane protein
|
|
gptkbp:substrate
|
gptkb:bradykinin
gptkb:enkephalins
gptkb:substance_P
gptkb:amyloid_beta_peptide
natriuretic peptides
|
|
gptkbp:UniProtID
|
P08473
|
|
gptkbp:bfsParent
|
gptkb:CD10
gptkb:amyloid_beta_protein
gptkb:Membrane_metallo-endopeptidase
gptkb:metalloprotease
|
|
gptkbp:bfsLayer
|
7
|