Ubiquitin-mediated proteolysis
GPTKB entity
Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:cause |
polyubiquitination
protein degradation by the 26S proteasome |
| gptkbp:discovery_awarded |
gptkb:Nobel_Prize_in_Chemistry_2004
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| https://www.w3.org/2000/01/rdf-schema#label |
Ubiquitin-mediated proteolysis
|
| gptkbp:involves |
gptkb:proteasome
gptkb:E1_ubiquitin-activating_enzyme gptkb:E2_ubiquitin-conjugating_enzyme E3 ubiquitin ligase ubiquitin |
| gptkbp:occurredIn |
eukaryotic cells
|
| gptkbp:regulates |
apoptosis
signal transduction immune response cell cycle protein degradation |
| gptkbp:type |
histone modification
|
| gptkbp:was_discovered_by |
gptkb:Aaron_Ciechanover
gptkb:Avram_Hershko gptkb:Irwin_Rose |
| gptkbp:bfsParent |
gptkb:WWP2
|
| gptkbp:bfsLayer |
7
|