|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ATP-dependent_helicase_WRN
gptkb:RECQ3
gptkb:Werner_protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Werner_syndrome
|
|
gptkbp:discoveredBy
|
gptkb:George_Martin
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
HRDC domain
RQC domain
RecQ helicase domain
exonuclease domain
|
|
gptkbp:Entrez_Gene_ID
|
7486
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.6.4.12
|
|
gptkbp:fullName
|
gptkb:Werner_syndrome_ATP-dependent_helicase
|
|
gptkbp:function
|
DNA helicase activity
exonuclease activity
|
|
gptkbp:gene
|
gptkb:WRN
|
|
gptkbp:GO_term
|
GO:0006281
GO:0004386
GO:0008408
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WRN (human)
|
|
gptkbp:interactsWith
|
gptkb:Ku70
gptkb:Ku80
gptkb:BLM
gptkb:FEN1
gptkb:RPA1
gptkb:TP53
|
|
gptkbp:length
|
1432 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p12
|
|
gptkbp:molecularWeight
|
162 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
genomic instability
premature aging
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Wrn
|
|
gptkbp:PDB
|
gptkb:2WWY
|
|
gptkbp:RefSeq
|
NP_000544.2
|
|
gptkbp:relatedTo
|
DNA repair
recombination
replication
telomere maintenance
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
gptkb:Q14191
|
|
gptkbp:bfsParent
|
gptkb:RecQ_helicase
|
|
gptkbp:bfsLayer
|
6
|