|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
FEN-1
MF1
RAD2
XPG-like endonuclease
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:biologicalProcess
|
DNA repair
DNA replication
flap endonuclease activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:Entrez_Gene_ID
|
2237
ENSG00000160307
|
|
gptkbp:enzyme
|
exonuclease
3'-flap endonuclease
5'-flap endonuclease
|
|
gptkbp:fullName
|
Flap endonuclease 1
|
|
gptkbp:function
|
DNA repair
DNA replication
Okazaki fragment processing
|
|
gptkbp:gene
|
gptkb:FEN1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:3602
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FEN1
|
|
gptkbp:interactsWith
|
gptkb:WRN
gptkb:PCNA
gptkb:DNA_polymerase_delta
APE1
|
|
gptkbp:length
|
380 amino acids
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:location
|
11q12.2
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
autoimmune disease
|
|
gptkbp:OMIM
|
600393
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse FEN1
yeast RAD27
|
|
gptkbp:PDB
|
1UL1
3Q8K
5UM9
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:RefSeq
|
NM_004111
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
mitochondria
|
|
gptkbp:UniProtID
|
P39748
|
|
gptkbp:bfsParent
|
gptkb:WRN_(human)
gptkb:PCNA
|
|
gptkbp:bfsLayer
|
7
|