Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Cockayne_syndrome
|
| gptkbp:affects |
both sexes
|
| gptkbp:associated_with |
gptkb:psychologist
cognitive decline fatigue sleep disturbances social isolation support groups chronic pain metabolic syndrome vision problems hearing loss fibrosis increased cancer risk muscle weakness cellular senescence chromosomal instability chronic kidney disease genetic counseling heart disease insulin resistance pulmonary fibrosis psychological issues atherosclerosis telomere shortening autoimmune disorders endocrine disorders increased oxidative stress neoplasia hypogonadism gastrointestinal issues palliative care needs dental problems joint problems thyroid dysfunction vascular complications mobility issues skin ulcers increased infections dyslipidemia hair graying quality of life decline |
| gptkbp:caused_by |
WRN gene mutation
|
| gptkbp:current_use |
gptkb:Bloom_syndrome
progeria |
| gptkbp:descendant |
autosomal recessive
|
| gptkbp:discovered_by |
gptkb:20th_century
|
| gptkbp:first_described_by |
Dr. Otto Werner
|
| gptkbp:function |
DNA helicase
|
| gptkbp:habitat |
chromosome 8
|
| https://www.w3.org/2000/01/rdf-schema#label |
Werner syndrome
|
| gptkbp:is_popular_in |
rare disorder
|
| gptkbp:lifespan |
shortened lifespan
|
| gptkbp:premiered_on |
adolescence to early adulthood
|
| gptkbp:research_focus |
aging mechanisms
|
| gptkbp:social_responsibility |
genetic testing
clinical evaluation |
| gptkbp:symptoms |
gptkb:Company
cataracts osteoporosis premature aging skin changes |
| gptkbp:treatment |
symptomatic management
|