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gptkbp:instanceOf
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gptkb:protein
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gptkbp:associatedWith
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DNA repair
genome stability
homologous recombination
replication fork maintenance
|
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gptkbp:cofactor
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gptkb:ATP
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gptkbp:discoveredBy
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gptkb:Ira_Herskowitz
|
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gptkbp:enzymeClassification
|
gptkb:EC_3.6.4.12
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gptkbp:foundIn
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gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
gptkb:Bacteria
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gptkbp:function
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DNA helicase activity
|
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gptkbp:gene
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gptkb:WRN
gptkb:RECQ
gptkb:RECQL1
gptkb:RECQL4
gptkb:RECQL5
gptkb:BLM
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|
https://www.w3.org/2000/01/rdf-schema#label
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RecQ helicase
|
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gptkbp:inhibitedBy
|
small molecule inhibitors (various)
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gptkbp:mechanismOfAction
|
resolves DNA secondary structures
unwinds DNA duplexes
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gptkbp:mutationAssociatedWith
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gptkb:Rothmund-Thomson_syndrome
gptkb:Werner_syndrome
gptkb:Bloom_syndrome
genomic instability
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gptkbp:orthologIn
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gptkb:BLM_(human)
gptkb:RECQL1_(human)
gptkb:RECQL4_(human)
gptkb:RECQL5_(human)
gptkb:RecQ_(bacteria)
gptkb:SGS1_(yeast)
gptkb:WRN_(human)
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gptkbp:relatedTo
|
aging
chromosome segregation
cancer predisposition
replication stress response
telomere maintenance
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gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkb:Annual_Review_of_Genetics
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gptkbp:structure
|
ATPase domain
HRDC domain
RQC domain
helicase domain
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gptkbp:substrate
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gptkb:gene
|
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gptkbp:bfsParent
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gptkb:Bloom_syndrome
|
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gptkbp:bfsLayer
|
5
|