|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
Tsc-2
Tsc2 gene
Tuberin
|
|
gptkbp:amendedBy
|
gptkb:Rheb_GTPase
|
|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis_complex
gptkb:lung_lymphangioleiomyomatosis
gptkb:subependymal_giant_cell_astrocytoma
epilepsy
renal angiomyolipoma
|
|
gptkbp:discoveredBy
|
gptkb:European_Chromosome_16_Tuberous_Sclerosis_Consortium
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
gptkb:tuberin
|
|
gptkbp:Entrez_Gene_ID
|
22020
ENSMUSG00000019966
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:fullName
|
tuberous sclerosis 2
|
|
gptkbp:function
|
tumor suppressor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tsc2
|
|
gptkbp:interactsWith
|
gptkb:Tsc1
|
|
gptkbp:involvedIn
|
gptkb:mTOR_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(mouse)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:tuberous_sclerosis
loss-of-function
|
|
gptkbp:OMIM
|
191092
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
human TSC2
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
AMPK signaling pathway
insulin signaling pathway
|
|
gptkbp:phosphorylates
|
gptkb:Akt
gptkb:AMPK
gptkb:RSK1
|
|
gptkbp:product
|
gptkb:tuberin
|
|
gptkbp:RefSeq
|
NM_011647
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell growth
cell size
|
|
gptkbp:UniProtID
|
gptkb:P49815
|
|
gptkbp:bfsParent
|
gptkb:TSC2
|
|
gptkbp:bfsLayer
|
6
|