Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
lipoprotein |
| gptkbp:activatedBy |
gptkb:Toll-like_receptor_4_(TLR4)
|
| gptkbp:cause |
septic shock
|
| gptkbp:chemicalFormula |
C82H162N2O23P2 (typical E. coli lipid A)
|
| gptkbp:composedOf |
fatty acids
glucosamine disaccharide backbone |
| gptkbp:discoveredBy |
gptkb:Otto_Westphal
|
| gptkbp:discoveredIn |
1952
|
| gptkbp:foundIn |
outer membrane of Gram-negative bacteria
|
| gptkbp:function |
endotoxin activity
|
| gptkbp:hasAcylChains |
true
|
| gptkbp:hasPhosphateGroup |
true
|
| https://www.w3.org/2000/01/rdf-schema#label |
lipid A
|
| gptkbp:partOf |
lipopolysaccharide
|
| gptkbp:recognizedBy |
innate immune system
|
| gptkbp:requires |
bacterial viability
|
| gptkbp:role |
immune response activation
|
| gptkbp:target |
antibiotic development
|
| gptkbp:toxicity |
mammals
|
| gptkbp:usedIn |
vaccine adjuvant research
|
| gptkbp:bfsParent |
gptkb:endotoxin
|
| gptkbp:bfsLayer |
5
|