Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:TGF-beta1
gptkb:Cedar gptkb:TGFB D4Ertd654e |
| gptkbp:associatedWith |
gptkb:cancer
inflammation fibrosis |
| gptkbp:discoveredIn |
1983
|
| gptkbp:encodes |
TGF-beta 1 protein
|
| gptkbp:Entrez_Gene_ID |
21803
ENSMUSG00000021253 |
| gptkbp:expressedIn |
many tissues
|
| gptkbp:fullName |
transforming growth factor beta 1
|
| gptkbp:function |
regulation of cell differentiation
regulation of cell growth extracellular matrix production immune system modulation |
| https://www.w3.org/2000/01/rdf-schema#label |
Tgfb1
|
| gptkbp:interactsWith |
gptkb:SMAD2
gptkb:SMAD3 gptkb:TGFBR2 gptkb:TGFBR1 gptkb:SMAD4 |
| gptkbp:length |
391 amino acids
|
| gptkbp:locatedOnChromosome |
7
|
| gptkbp:location |
7 F5
|
| gptkbp:mainTerminal |
GO:0005615 (extracellular space)
GO:0008285 (negative regulation of cell proliferation) GO:0006954 (inflammatory response) GO:0007179 (transforming growth factor beta receptor signaling pathway) |
| gptkbp:mgiID |
MGI:98787
|
| gptkbp:molecularWeight |
44 kDa
|
| gptkbp:mutationAssociatedWith |
inflammatory bowel disease
developmental defects impaired immune response |
| gptkbp:organism |
gptkb:Mus_musculus
|
| gptkbp:orthologIn |
TGFB1 (human)
|
| gptkbp:pathway |
gptkb:TGF-beta_signaling_pathway
|
| gptkbp:proteinFamily |
gptkb:TGF-beta_superfamily
|
| gptkbp:regulates |
apoptosis
cell proliferation wound healing angiogenesis immune response extracellular matrix organization |
| gptkbp:UniProtID |
P04202
|
| gptkbp:bfsParent |
gptkb:chromosome_7_(mouse)
|
| gptkbp:bfsLayer |
7
|