Transforming Growth Factor alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	TGF-α
gptkbp:binds	gptkb:EGFR
gptkbp:category	gptkb:cytokine gptkb:growth_factor gptkb:signaling_molecule mitogen
gptkbp:discoveredBy	gptkb:Stanley_Cohen
gptkbp:discoveredIn	1980s
gptkbp:encodedBy	gptkb:TGFA_gene
gptkbp:Entrez_Gene_ID	7039
gptkbp:expressedIn	gptkb:cancer gptkb:kidney gptkb:keratinocytes brain gastrointestinal tract macrophages
gptkbp:foundIn	humans mice
gptkbp:function	cell proliferation epithelial development
gptkbp:HGNC_ID	11742
gptkbp:involvedIn	wound healing tumorigenesis
gptkbp:length	50 amino acids (mature form)
gptkbp:locatedOnChromosome	chromosome 2p13 (human)
gptkbp:OMIM	190170
gptkbp:orthologIn	gptkb:epidermal_growth_factor
gptkbp:PDB	1TGF
gptkbp:predecessor	160 amino acids
gptkbp:recipient	gptkb:epidermal_growth_factor_receptor
gptkbp:RefSeq	NM_003236
gptkbp:relatedTo	gptkb:epidermal_growth_factor
gptkbp:role	angiogenesis cancer progression tissue regeneration embryogenesis
gptkbp:structure	polypeptide
gptkbp:UniProtID	gptkb:P01135
gptkbp:bfsParent	gptkb:TGF-alpha
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	Transforming Growth Factor alpha