Transforming Growth Factor alpha

URI: https://gptkb.org/entity/Transforming_Growth_Factor_alpha
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation TGF-α
gptkbp:binds gptkb:EGFR
gptkbp:category growth factor
signaling molecule
cytokine
mitogen
gptkbp:discoveredBy gptkb:Stanley_Cohen
gptkbp:discoveredIn 1980s
gptkbp:encodedBy gptkb:TGFA_gene
gptkbp:Entrez_Gene_ID 7039
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
gptkb:keratinocytes
brain
gastrointestinal tract
macrophages
gptkbp:foundIn humans
mice
gptkbp:function cell proliferation
epithelial development
gptkbp:HGNC_ID 11742
https://www.w3.org/2000/01/rdf-schema#label Transforming Growth Factor alpha
gptkbp:involvedIn wound healing
tumorigenesis
gptkbp:length 50 amino acids (mature form)
gptkbp:locatedOnChromosome chromosome 2p13 (human)
gptkbp:OMIM 190170
gptkbp:orthologIn gptkb:epidermal_growth_factor
gptkbp:PDB 1TGF
gptkbp:predecessor 160 amino acids
gptkbp:recipient gptkb:epidermal_growth_factor_receptor
gptkbp:RefSeq NM_003236
gptkbp:relatedTo gptkb:epidermal_growth_factor
gptkbp:role angiogenesis
cancer progression
tissue regeneration
embryogenesis
gptkbp:structure polypeptide
gptkbp:UniProtID gptkb:P01135
gptkbp:bfsParent gptkb:TGF-alpha
gptkbp:bfsLayer 7