Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
beta-lactamase |
| gptkbp:discoveredIn |
1960s
|
| gptkbp:encodedBy |
chromosomal band
plasmids |
| gptkbp:firstDescribed |
gptkb:Greece
|
| gptkbp:foundIn |
gptkb:Bacteria
gptkb:Klebsiella_pneumoniae |
| gptkbp:gene |
gptkb:blaTEM
|
| gptkbp:grapeVariety |
gptkb:TEM-1
gptkb:TEM-2 gptkb:TEM-3 |
| gptkbp:hasVariant |
over 200
|
| https://www.w3.org/2000/01/rdf-schema#label |
TEM beta-lactamase
|
| gptkbp:inhibitedBy |
gptkb:clavulanic_acid
gptkb:sulbactam tazobactam |
| gptkbp:mechanismOfAction |
hydrolyzes beta-lactam ring
|
| gptkbp:mutationAssociatedWith |
extended-spectrum beta-lactamase (ESBL) activity
|
| gptkbp:namedAfter |
gptkb:Temoniera
|
| gptkbp:resistantTo |
gptkb:beta-lactam_antibiotics
gptkb:ampicillin gptkb:cephalosporins penicillins |
| gptkbp:significance |
antibiotic resistance
|
| gptkbp:spreadTo |
horizontal gene transfer
|
| gptkbp:structure |
serine active site
|
| gptkbp:superfamily |
class A beta-lactamase
|
| gptkbp:bfsParent |
gptkb:SHV
gptkb:Beta-lactamase |
| gptkbp:bfsLayer |
7
|