beta-lactam antibiotics

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:antibiotic
gptkbp:canBeInactivatedBy beta-lactamase enzymes
gptkbp:chemicalFormula contains four-membered lactam ring
gptkbp:combines beta-lactamase inhibitors
gptkbp:concerns gptkb:carbapenem-resistant_Enterobacteriaceae
gptkb:MRSA
ESBL-producing bacteria
gptkbp:contains beta-lactam ring
gptkbp:contraindication penicillin allergy
gptkbp:discoveredBy gptkb:antibiotic
1928
Alexander Fleming (penicillin)
gptkbp:drugInteraction may reduce efficacy of oral contraceptives
gptkbp:example gptkb:amoxicillin
gptkb:aztreonam
gptkb:ceftriaxone
gptkb:imipenem
https://www.w3.org/2000/01/rdf-schema#label beta-lactam antibiotics
gptkbp:includes gptkb:cephalosporins
gptkb:monobactams
penicillins
carbapenems
gptkbp:mechanismOfAction inhibit bacterial cell wall synthesis
gptkbp:metabolism mainly renal excretion
gptkbp:namedAfter beta-lactam ring
gptkbp:pregnancyCategory generally safe
gptkbp:resistantTo beta-lactamase production
gptkbp:routeOfAdministration oral
intramuscular
intravenous
gptkbp:sideEffect diarrhea
allergic reaction
rash
gptkbp:spectrumOfActivity broad-spectrum
narrow-spectrum
gptkbp:subclassOf antibacterial drugs
gptkbp:target penicillin-binding proteins
gptkbp:usedFor gptkb:pneumonia
meningitis
skin infections
sepsis
urinary tract infections
bacterial infections
gptkbp:usedIn gptkb:veterinary_medicine
human medicine
gptkbp:WHOStatus gptkb:Essential_Medicines
gptkbp:bfsParent gptkb:Beta
gptkbp:bfsLayer 5