Suppressor of cytokine signaling
GPTKB entity
Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:SOCS
|
| gptkbp:associatedWith |
gptkb:cancer
autoimmune disease |
| gptkbp:biologicalProcess |
enzyme inhibitor activity
protein binding |
| gptkbp:discoveredBy |
gptkb:Douglas_J._Hilton
|
| gptkbp:domain |
gptkb:SOCS_box
SH2 domain |
| gptkbp:encodedBy |
SOCS genes
|
| gptkbp:firstDescribed |
1997
|
| gptkbp:foundIn |
mammals
|
| gptkbp:function |
negative regulation of cytokine signaling
|
| gptkbp:GO_term |
GO:0039502
|
| gptkbp:hasMember |
gptkb:SOCS1
gptkb:SOCS2 gptkb:SOCS3 gptkb:SOCS4 gptkb:SOCS5 gptkb:SOCS6 gptkb:SOCS7 gptkb:CISH |
| https://www.w3.org/2000/01/rdf-schema#label |
Suppressor of cytokine signaling
|
| gptkbp:inhibitedBy |
gptkb:STAT_proteins
gptkb:JAK_kinases cytokine receptor signaling |
| gptkbp:ortholog_found_in |
gptkb:human
gptkb:mouse gptkb:zebrafish right |
| gptkbp:regulates |
gptkb:JAK-STAT_signaling_pathway
apoptosis cell proliferation signal transduction inflammation immune response interferon signaling insulin signaling growth hormone signaling interleukin signaling prolactin signaling hematopoiesis tyrosine kinase activity growth factor signaling cytokine receptor signaling erythropoietin signaling leptin signaling thrombopoietin signaling colony-stimulating factor signaling |
| gptkbp:bfsParent |
gptkb:SOCS_box
|
| gptkbp:bfsLayer |
7
|