Suppressor of cytokine signaling

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:SOCS
gptkbp:associatedWith	gptkb:autoimmune_disease gptkb:cancer
gptkbp:biologicalProcess	enzyme inhibitor activity protein binding
gptkbp:discoveredBy	gptkb:Douglas_J._Hilton
gptkbp:domain	gptkb:SOCS_box SH2 domain
gptkbp:encodedBy	SOCS genes
gptkbp:firstDescribed	1997
gptkbp:foundIn	mammals
gptkbp:function	negative regulation of cytokine signaling
gptkbp:GO_term	GO:0039502
gptkbp:hasMember	gptkb:SOCS1 gptkb:SOCS2 gptkb:SOCS3 gptkb:SOCS4 gptkb:SOCS5 gptkb:SOCS6 gptkb:SOCS7 gptkb:CISH
gptkbp:inhibitedBy	gptkb:STAT_proteins gptkb:JAK_kinases cytokine receptor signaling
gptkbp:ortholog_found_in	gptkb:human gptkb:mouse gptkb:right gptkb:zebrafish
gptkbp:regulates	gptkb:JAK-STAT_signaling_pathway gptkb:immune_response apoptosis cell proliferation signal transduction inflammation interferon signaling insulin signaling growth hormone signaling interleukin signaling prolactin signaling hematopoiesis tyrosine kinase activity growth factor signaling cytokine receptor signaling erythropoietin signaling leptin signaling thrombopoietin signaling colony-stimulating factor signaling
gptkbp:bfsParent	gptkb:SOCS_box
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Suppressor of cytokine signaling