|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:biologicalProcess
|
transcriptional activation
DNA-binding
transcriptional repression
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Tjian
|
|
gptkbp:discoveredIn
|
1981
|
|
gptkbp:domain
|
zinc finger domain
DNA-binding domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:SP1_gene
|
|
gptkbp:Entrez_Gene_ID
|
6667
ENSG00000185591
|
|
gptkbp:function
|
regulation of gene expression
binds GC-rich motifs in DNA
|
|
gptkbp:gene
|
gptkb:SP1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SP1 transcription factor
|
|
gptkbp:interactsWith
|
gptkb:c-Jun
gptkb:CBP/p300
gptkb:TATA-binding_protein
gptkb:E2F1
gptkb:HDAC1
gptkb:p53
gptkb:STAT3
NF-Y
|
|
gptkbp:length
|
785
|
|
gptkbp:locatedOnChromosome
|
12q13.1
|
|
gptkbp:OMIM
|
189906
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
sumoylation
acetylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
DNA repair
metabolism
angiogenesis
immune response
cell cycle
tumor suppressor genes
oncogene expression
chromatin remodeling
|
|
gptkbp:UniProtID
|
P08047
|
|
gptkbp:bfsParent
|
gptkb:SP2_transcription_factor
|
|
gptkbp:bfsLayer
|
8
|