Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
gene expression regulation
|
| gptkbp:associated_with |
chromatin remodeling
eukaryotic transcription nuclear transcription factors transcriptional factors |
| gptkbp:binding_domain |
TBP domain
|
| gptkbp:binding_mechanism |
specificity for TATA box sequences
|
| gptkbp:binding_site |
TATA box
|
| gptkbp:breeding_range |
chromosome 6 in humans
|
| gptkbp:cellular_location |
nuclear speckles
|
| gptkbp:clinical_trial |
target for cancer therapies
implicated in certain diseases |
| gptkbp:complex_formation |
with other transcription factors
|
| gptkbp:discovery_year |
gptkb:1980s
|
| gptkbp:family |
gptkb:TATA-binding_proteins
|
| gptkbp:financial_stability |
influenced by binding partners
|
| gptkbp:function |
DNA transcription
mediates the assembly of the transcription machinery RNA polymerase I and III transcription binds to the TATA box in DNA recruits other transcription machinery regulates transcriptional activity stabilizes the transcription complex |
| gptkbp:genetic_studies |
can lead to transcriptional dysregulation
|
| gptkbp:homologs |
found in various species
|
| https://www.w3.org/2000/01/rdf-schema#label |
TATA-binding protein
|
| gptkbp:importance |
essential for accurate transcription initiation
|
| gptkbp:initiated_by |
identified in drug discovery
|
| gptkbp:interacts_with |
gptkb:DNA
transcription factors with RNA polymerase II |
| gptkbp:involved_in |
DNA damage response
signal transduction pathways RNA processing protein-protein interactions formation of the pre-initiation complex m RNA synthesis |
| gptkbp:is_expressed_in |
ubiquitous in tissues
|
| gptkbp:knockouts |
high for TATA box sequences
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:modifications |
phosphorylation
|
| gptkbp:mutation_impact |
can affect gene expression
|
| gptkbp:originated_in |
conserved across eukaryotes
|
| gptkbp:orthologs |
found in yeast and other organisms
|
| gptkbp:promoter |
TBP
|
| gptkbp:regulatory_compliance |
in transcriptional activation
|
| gptkbp:research |
X-ray crystallography
|
| gptkbp:research_areas |
molecular biology
|
| gptkbp:role |
cell cycle regulation
cellular stress response developmental processes transcriptional repression initiates transcription by RNA polymerase II |
| gptkbp:structure |
consists of a C-terminal domain and an N-terminal domain
has been solved |
| gptkbp:theory |
TBP-associated factors (TAFs)
|
| gptkbp:type |
general transcription factor
|
| gptkbp:weight |
approximately 38 k Da
|
| gptkbp:bfsParent |
gptkb:RNA_Polymerase_II
|
| gptkbp:bfsLayer |
5
|