Retinoblastoma protein (RB1)

URI: https://gptkb.org/entity/Retinoblastoma_protein_(RB1)
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:RB_protein
gptkb:pRb
gptkbp:decommissioned phosphorylation
gptkbp:dephosphorylatedBy gptkb:protein_phosphatase_1
gptkbp:discoveredBy gptkb:Alfred_G._Knudson
gptkbp:encodedBy gptkb:RB1_gene
gptkbp:expressedIn many tissues
gptkbp:form hypophosphorylated
gptkbp:function tumor suppressor
regulation of cell cycle
gptkbp:HGNC_ID 9884
https://www.w3.org/2000/01/rdf-schema#label Retinoblastoma protein (RB1)
gptkbp:inactiveForm hyperphosphorylated
gptkbp:inhibitedBy gptkb:E2F_transcription_factors
gptkbp:interactsWith gptkb:MDM2
gptkb:BRCA1
gptkb:DP1
gptkb:E2F1
gptkb:HDAC1
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome 13q14.2
gptkbp:molecularWeight ~110 kDa
gptkbp:mutationAssociatedWith gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
gptkbp:OMIM 614041
gptkbp:PDB 1AD6
gptkbp:phosphorylates gptkb:cyclin-dependent_kinases
gptkbp:regulates gptkb:G1/S_transition
apoptosis
cell differentiation
DNA replication
gptkbp:role hereditary cancer syndromes
sporadic cancers
gptkbp:UniProtID P06400
gptkbp:bfsParent gptkb:RBBP3
gptkb:Serine/threonine-protein_kinase_CDK4
gptkbp:bfsLayer 8