|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeState
|
GTP-bound
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:composedOf
|
small GTPases
|
|
gptkbp:contains
|
G domain
|
|
gptkbp:database
|
gptkb:InterPro:_IPR001806
gptkb:Pfam:_PF00071
Gene Ontology: GO:0005525
|
|
gptkbp:discoveredBy
|
biochemical studies in the 1980s
|
|
gptkbp:example
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
gptkb:Ran
gptkb:Arf1
gptkb:Rab5
gptkb:RhoA
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
molecular switches
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras superfamily proteins
|
|
gptkbp:inactiveState
|
GDP-bound
|
|
gptkbp:involves
|
gptkb:cancer
developmental disorders
neurological diseases
|
|
gptkbp:molecularWeightRange
|
~20-40 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenesis
|
|
gptkbp:proteinFamily
|
gptkb:Ras_gene_family
Arf gene family
Rab gene family
Ran gene family
Rho gene family
|
|
gptkbp:regulates
|
gptkb:GDIs_(guanine_nucleotide_dissociation_inhibitors)
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
cell differentiation
cell proliferation
cell survival
vesicle trafficking
cell migration
cytoskeletal organization
nuclear transport
|
|
gptkbp:structure
|
conserved GTPase fold
|
|
gptkbp:subfamily
|
gptkb:Rab
gptkb:Ran
gptkb:Arf
gptkb:Ras
gptkb:Rho
|
|
gptkbp:bfsParent
|
gptkb:G-domain
gptkb:G3_motif
|
|
gptkbp:bfsLayer
|
7
|