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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:PIK3C3
gptkb:class_III_PI3K
gptkb:Vacuolar_protein_sorting_34
|
|
gptkbp:discoveredIn
|
gptkb:Saccharomyces_cerevisiae
|
|
gptkbp:EC_number
|
2.7.1.137
|
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gptkbp:function
|
regulates endocytosis
regulates autophagy
regulates vesicle trafficking
phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
|
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gptkbp:gene
|
gptkb:PIK3C3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3-kinase Vps34
|
|
gptkbp:inhibitedBy
|
gptkb:Wortmannin
gptkb:3-Methyladenine
gptkb:SAR405
|
|
gptkbp:interactsWith
|
gptkb:Beclin-1
gptkb:UVRAG
gptkb:Vps15
gptkb:Atg14L
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:autophagosomes
endosomes
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_18q12.3
|
|
gptkbp:molecularWeight
|
101 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurodegeneration
autophagy defects
impaired endocytosis
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:yeast_Vps34
|
|
gptkbp:pathway
|
autophagy pathway
phosphoinositide metabolism
endocytic pathway
|
|
gptkbp:PDB
|
5DFZ
|
|
gptkbp:phosphorylates
|
phosphatidylinositol
|
|
gptkbp:regulates
|
activated by nutrient availability
regulated by AMPK
regulated by mTOR
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkb:Journal_of_Biological_Chemistry
Cell
|
|
gptkbp:significance
|
potential target in cancer therapy
potential target in neurodegenerative diseases
|
|
gptkbp:structure
|
contains C2 domain
contains PI3K catalytic domain
|
|
gptkbp:subunit
|
gptkb:class_III_PI3-kinase_complex
|
|
gptkbp:UniProtID
|
gptkb:Q8NEB9
|
|
gptkbp:bfsParent
|
gptkb:Rab5
|
|
gptkbp:bfsLayer
|
6
|