|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:DJ-1
gptkb:Parkinson_disease_protein_7
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
|
|
gptkbp:biologicalProcess
|
regulation of transcription
cellular response to oxidative stress
protein deglycation
|
|
gptkbp:discoveredBy
|
gptkb:Nagakubo_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:diseaseRole
|
oncogenesis
neuroprotection
|
|
gptkbp:encodedBy
|
gptkb:PARK7_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:PARK7
|
|
gptkbp:enzymeClassification
|
EC 3.5.1.-
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
oxidative stress response
deglycase activity
transcriptional coactivator
|
|
gptkbp:GO_term
|
gptkb:GO:0019240_(protein_deglycation)
gptkb:GO:0034599_(cellular_response_to_oxidative_stress)
GO:0005739 (mitochondrion)
GO:0005634 (nucleus)
GO:0005829 (cytosol)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protein deglycase DJ-1
|
|
gptkbp:interactsWith
|
gptkb:PINK1
gptkb:SOD1
gptkb:Parkin
ASK1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36
|
|
gptkbp:molecularWeight
|
20 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:early-onset_Parkinson's_disease
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1P5F
|
|
gptkbp:postTranslationalModification
|
oxidation
sumoylation
|
|
gptkbp:sequence
|
189 amino acids
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:UniProtID
|
Q99497
|
|
gptkbp:bfsParent
|
gptkb:DJ-1
|
|
gptkbp:bfsLayer
|
7
|