|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:BRPK
gptkb:PARK6
gptkb:RKN1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
|
|
gptkbp:component
|
mitochondrial outer membrane
|
|
gptkbp:discoveredBy
|
gptkb:Valina_L._Dawson
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:encodedBy
|
gptkb:PINK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000158828
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
heart
|
|
gptkbp:fullName
|
gptkb:PTEN-induced_putative_kinase_1
|
|
gptkbp:function
|
protein serine/threonine kinase activity
serine/threonine kinase activity
mitochondrial quality control
|
|
gptkbp:gene
|
gptkb:PINK1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
mitophagy
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PINK1
|
|
gptkbp:interactsWith
|
gptkb:Parkin
|
|
gptkbp:length
|
581 amino acids
|
|
gptkbp:locale
|
mitochondria
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:early-onset_Parkinson's_disease
nonsense
missense
neuronal cell death
frameshift
impaired mitophagy
mitochondrial dysfunction
|
|
gptkbp:OMIM
|
608309
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
mitophagy pathway
|
|
gptkbp:phosphorylates
|
gptkb:Parkin
ubiquitin
|
|
gptkbp:RefSeq
|
gptkb:NM_032409
|
|
gptkbp:regulates
|
mitochondrial dynamics
mitochondrial fission
mitochondrial fusion
|
|
gptkbp:reviewedBy
|
gptkb:GeneReviews
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:UniProtID
|
gptkb:Q9BXM7
|
|
gptkbp:bfsParent
|
gptkb:juvenile_Parkinson's_disease
gptkb:Parkin
|
|
gptkbp:bfsLayer
|
6
|