|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PARK7
gptkb:Protein_deglycase_DJ-1
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
|
|
gptkbp:discoveredBy
|
gptkb:Nagakubo_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:PARK7_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
acts as a redox-sensitive chaperone
deglycase activity
protects cells against oxidative stress
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DJ-1
|
|
gptkbp:involvedIn
|
regulation of transcription
cellular response to oxidative stress
protection against cell death
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36.23
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
20 kDa
|
|
gptkbp:mutationAssociatedWith
|
linked to early-onset Parkinson's disease
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1P5F
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
Q99497
|
|
gptkbp:bfsParent
|
gptkb:juvenile_Parkinson's_disease
gptkb:Parkin
|
|
gptkbp:bfsLayer
|
6
|