Parkinson disease protein 7

URI: https://gptkb.org/entity/Parkinson_disease_protein_7
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:DJ-1
gptkbp:associatedWith gptkb:Parkinson's_disease
gptkbp:discoveredBy gptkb:Tak_Mak
gptkbp:discoveredIn 2001
gptkbp:encodedBy gptkb:PARK7_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000116288
11315
gptkbp:function acts as a redox-sensitive chaperone
deglycase activity
protects cells against oxidative stress
https://www.w3.org/2000/01/rdf-schema#label Parkinson disease protein 7
gptkbp:interactsWith gptkb:alpha-synuclein
gptkb:PINK1
gptkb:Parkin
gptkbp:length 189 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_1p36
gptkbp:molecularWeight 20 kDa
gptkbp:mutationAssociatedWith linked to autosomal recessive early-onset Parkinson's disease
gptkbp:OMIM 606324
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 1P5F
gptkbp:postTranslationalModification phosphorylation
oxidation
sumoylation
gptkbp:RefSeq NP_009193.2
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
mitochondria
gptkbp:UniProtID Q99497
gptkbp:bfsParent gptkb:Protein_deglycase_DJ-1
gptkbp:bfsLayer 8