Programmed cell death protein 1
GPTKB entity
Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:T_cells
HIV infection |
| gptkbp:discovered_by |
gptkb:1992
|
| gptkbp:function |
regulates immune response
|
| gptkbp:has_role |
tumor microenvironment
autoimmunity |
| https://www.w3.org/2000/01/rdf-schema#label |
Programmed cell death protein 1
|
| gptkbp:initiated_by |
T cell activation
cytokine production |
| gptkbp:interacts_with |
gptkb:PD-L1
|
| gptkbp:involved_in |
cancer immunotherapy
T cell exhaustion |
| gptkbp:is_associated_with |
metastatic cancer
viral infections immune evasion chronic inflammatory conditions lymphocyte activation |
| gptkbp:is_expressed_in |
gptkb:Cell
myeloid cells plasma cells dendritic cells natural killer cells tumor cells monocytes tumor-infiltrating lymphocytes activated T cells activated B cells |
| gptkbp:is_involved_in |
regulation of apoptosis
therapeutic interventions disease progression immune tolerance cellular signaling pathways T cell differentiation immune response modulation tumor microenvironment interactions cancer treatment strategies immune checkpoint blockade immune checkpoint inhibition immune cell signaling immune system regulation tumor escape mechanisms immune checkpoint therapy cancer cell immune evasion cancer cell proliferation B cell regulation T regulatory cell function tumor immune response |
| gptkbp:is_linked_to |
gptkb:Oncology
gptkb:neurodegenerative_diseases autoimmune diseases inflammatory diseases chronic infections |
| gptkbp:is_located_in |
chromosome 2
|
| gptkbp:is_part_of |
immune checkpoint pathway
|
| gptkbp:is_regulated_by |
cytokines
|
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
monoclonal antibodies
checkpoint inhibitors anti-PD-1 therapies |
| gptkbp:promoter |
gptkb:PDCD1
|
| gptkbp:bfsParent |
gptkb:PD-1
|
| gptkbp:bfsLayer |
6
|