Programmed cell death protein 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:immunotherapy gptkb:protein
gptkbp:abbreviation	gptkb:PD-1
gptkbp:alternativeName	gptkb:CD279
gptkbp:associatedWith	gptkb:cancer autoimmune diseases
gptkbp:discoveredIn	1992
gptkbp:encodedBy	gptkb:PDCD1_gene
gptkbp:Entrez_Gene_ID	ENSG00000188389
gptkbp:expressedIn	gptkb:B_cells gptkb:T_cells monocytes
gptkbp:extracellularDomain	IgV-like domain
gptkbp:foundIn	humans mice
gptkbp:function	inhibits immune response
gptkbp:HGNC_ID	8765
gptkbp:inhibitedBy	cytokine production T cell proliferation
gptkbp:intracellularDomain	ITIM motif ITSM motif
gptkbp:ligand	gptkb:PD-L2 PD-L1
gptkbp:locatedOn	cell surface
gptkbp:locatedOnChromosome	chromosome 2q37.3
gptkbp:modulatedBy	gptkb:interferon_gamma inflammatory cytokines
gptkbp:molecularWeight	55 kDa
gptkbp:OMIM	600244
gptkbp:PDB	3RRQ
gptkbp:regulates	T cell activation immune tolerance
gptkbp:role	immune evasion by tumors chronic infection T cell exhaustion
gptkbp:structure	type I transmembrane protein
gptkbp:target	gptkb:immunotherapy checkpoint inhibitors
gptkbp:targetOfDrug	gptkb:non-small_cell_lung_cancer gptkb:renal_cell_carcinoma gptkb:head_and_neck_squamous_cell_carcinoma gptkb:pembrolizumab gptkb:cemiplimab gptkb:nivolumab gptkb:melanoma Hodgkin lymphoma
gptkbp:UniProtID	Q15116
gptkbp:bfsParent	gptkb:CD279 gptkb:PD-1
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Programmed cell death protein 1