Programmed cell death protein 1
GPTKB entity
Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:T_cells
HIV infection |
| gptkbp:discovered_by |
gptkb:1992
|
| gptkbp:established |
T cell activation
cytokine production |
| gptkbp:function |
regulates immune response
|
| gptkbp:has_role |
tumor microenvironment
autoimmunity |
| https://www.w3.org/2000/01/rdf-schema#label |
Programmed cell death protein 1
|
| gptkbp:interacts_with |
gptkb:PD-L1
|
| gptkbp:is_aimed_at |
monoclonal antibodies
checkpoint inhibitors anti-PD-1 therapies |
| gptkbp:is_associated_with |
metastatic cancer
viral infections immune evasion chronic inflammatory conditions lymphocyte activation |
| gptkbp:is_involved_in |
regulation of apoptosis
therapeutic interventions disease progression immune tolerance cellular signaling pathways T cell differentiation immune response modulation cancer immunotherapy tumor microenvironment interactions cancer treatment strategies immune checkpoint blockade immune checkpoint inhibition immune cell signaling immune system regulation tumor escape mechanisms immune checkpoint therapy T cell exhaustion cancer cell immune evasion cancer cell proliferation B cell regulation T regulatory cell function tumor immune response |
| gptkbp:is_linked_to |
gptkb:healthcare_organization
gptkb:psychologist autoimmune diseases inflammatory diseases chronic infections |
| gptkbp:is_part_of |
immune checkpoint pathway
|
| gptkbp:is_represented_in |
gptkb:smartphone
myeloid cells plasma cells dendritic cells natural killer cells tumor cells monocytes tumor-infiltrating lymphocytes activated T cells activated B cells |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:located_in |
chromosome 2
|
| gptkbp:promoter |
PDC D1
|
| gptkbp:regulates |
cytokines
|
| gptkbp:bfsParent |
gptkb:PD-1
|
| gptkbp:bfsLayer |
5
|