Programmed cell death protein 1

URI: https://gptkb.org/entity/Programmed_cell_death_protein_1
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
immunotherapy
gptkbp:abbreviation gptkb:PD-1
gptkbp:alternativeName gptkb:CD279
gptkbp:associatedWith gptkb:cancer
autoimmune diseases
gptkbp:discoveredIn 1992
gptkbp:encodedBy gptkb:PDCD1_gene
gptkbp:Entrez_Gene_ID ENSG00000188389
gptkbp:expressedIn gptkb:B_cells
gptkb:T_cells
monocytes
gptkbp:extracellularDomain IgV-like domain
gptkbp:foundIn humans
mice
gptkbp:function inhibits immune response
gptkbp:HGNC_ID 8765
https://www.w3.org/2000/01/rdf-schema#label Programmed cell death protein 1
gptkbp:inhibitedBy cytokine production
T cell proliferation
gptkbp:intracellularDomain ITIM motif
ITSM motif
gptkbp:ligand gptkb:PD-L2
PD-L1
gptkbp:locatedOn cell surface
gptkbp:locatedOnChromosome chromosome 2q37.3
gptkbp:modulatedBy gptkb:interferon_gamma
inflammatory cytokines
gptkbp:molecularWeight 55 kDa
gptkbp:OMIM 600244
gptkbp:PDB 3RRQ
gptkbp:regulates T cell activation
immune tolerance
gptkbp:role immune evasion by tumors
chronic infection
T cell exhaustion
gptkbp:structure type I transmembrane protein
gptkbp:target immunotherapy
checkpoint inhibitors
gptkbp:targetOfDrug gptkb:non-small_cell_lung_cancer
gptkb:head_and_neck_squamous_cell_carcinoma
gptkb:pembrolizumab
gptkb:cemiplimab
gptkb:nivolumab
melanoma
Hodgkin lymphoma
renal cell carcinoma
gptkbp:UniProtID Q15116
gptkbp:bfsParent gptkb:PD1
gptkb:PDCD1_gene
gptkb:CD279
gptkbp:bfsLayer 7